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In addition, engineered bacteria are a promising carrier for drug delivery, and today substantial studies are using engineered bacteria for targeted delivery of interfering RNA (Jiang et al., 2007), DNA vaccines (Kong et al., 2012), proteins (Xie et al., 2017) for the treatment of malignant tumors

Oxidative Med Cell Longev 2019:1759149 [DOI] [PMC free article] [PubMed] [Google Scholar] Whittle S, Hughes R (2004) Folate supplementation and methotrexate treatment in rheumatoid arthritis: a review

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In HK-2 cells, an increase in BHB levels activated the TGF- signaling pathway, leading to enhanced protein expression of P21 and P27