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investigated the therapeutic mechanisms of MSCs and found that human adipose-derived mesenchymal stem cells (hAd-MSCs) had postradiation healing effects, including anti-inflammation, neovascularization and maintenance of epithelium homeostasis, as indicated by the elevated serum IL-10, upregulation of vascular endothelial growth factor, basic fibroblast growth factor and epidermal growth factor in irradiated intestine, mobilization of CD31-positive hematopoietic stem cells or hematopoietic progenitor cells, and the prolonged presence of Bmi1-positive cells within crypts

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The time required for healing varies depending on the extent of tissue damage and the bodys natural recovery response

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