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Pharmacological comparison of mitragynine and 7-hydroxymitragynine: In vitro affinity and efficacy for -opioid receptor and opioid-like behavioral effects in rats

Following treatment, media was replaced with 80% (v/v) methanol (cooled to 80 C.) containing 500 nmol 6-chloronicotinamide (6-CN) as an internal standard (IS) to extract cellular metabolites

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