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Later on, it has been shown that more than 200 variants exist in the coding region of TMAO producing enzyme, with different outcomes on the cardiovascular risk (Phillips and Shephard, 2020)

Because these lipotropics are structurally and functionally closely related to the B-vitams, they are often employed together in the hope of potentiating the potential for fat-loss, thus while the MIC mixture and B vitamin(s) are often injected separately, they are part of the same overall injection cycle