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1-6 Based on receptor availability at the tissues, estradiol is converted to estrone and further converted to estriol through the 16-alpha-hydroxyestrone metabolism pathway during Phase I metabolism

Additionally, the promoter features an antioxidant response element (ARE) and metal response element (MRE) within the first 160 bp of the transcription start point, which respond to oxidative stimuli such as H 2 O 2 and tert-butylhydroquinone [35]

With rigorous preclinical and clinical evaluation, PLGA nanoparticle systems hold strong potential for successful translation from bench to bedside

The second, third, and fourth group received an oral dose of Sildenafil (1.48 mg/kg), Tadalafil (0.285 mg/kg), and Vardenafil (0.285 mg/kg) respectively, three times per week for 12 weeks