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Overall, it is regarded as the third most common malignancy [178]

Mitochondrial redox control For mitochondrial redox control, the rationale is that reverse electron transport (RET) at complex I, sustained elevation of m, Ca overload and high-flux activity at the I_Q/III_Qo sites generate matrix and intermembrane-space ROS bursts that flip physiological signalling into damage during stress states such as ischemiareperfusion (Gibbs et al