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Table (3): ADME validation of the metabolites from Burkholderia stagnalis Selected bioactive metabolites obeyed Lipinskis rule of 5 without any violation suggesting their possibility of oral administration, The boiled egg plot evaluate the pharmacokinetic properties of the 24 bioactive metabolites, helping to predict their bioavailability and potential therapeutic applications (Figure 6)

Lipids, glucose, and amino acids are extensively studied metabolites that underpin T cell survival, activation, and lineage differentiation [2,3,4]

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Ferroptosis contributes to follicular depletion, ultimately leading to DOR (Figure 4B)