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Spermidine and spermine can exert bone protective effects , where they prevent ovariectomy-induced bone loss by inhibiting osteoclast differentiation and maturation without impairing cell viability

Small number of research groups : A limited number of research groups have conducted most studies, which may affect the generalizability of the results

Long duration does not mean that improvement is impossible, but treatment usually needs a structured approach that addresses both nerve sensitization and contributing factors