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The brainstem-cortex network plays a critical role in the migraine pathway, with conditions such as insomnia, obstructive sleep apnea, sleep-related movement disorders, and REM sleep disturbances closely associated with migraine onset (Vgontzas and Pavlovi, 2018)

The derivative acetyl-L-carnitine plays a crucial role in cognitive function, and L-carnitine supplementation improves the behavior of aging people, patients with Alzheimers disease, and patients with Parkinsons disease

Taken together, mitochondrial abnormalities are closely associated with synaptic aberrations, including impaired synaptic transmission, in various ASD-related syndromes of genetic origin (Table 2)

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