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[DOI] [PMC free article] [PubMed] [Google Scholar] 72.Talmadge JE, Gabrilovich DI

Valneva began the research for VLA15 in Europe utilizing four Borrelia s pecies presenting six different outer surface protein A (OspA) serotypes (ST) that are responsible for the majority of human clinical cases: Borrelia burgdorferi (OspA ST1), Borrelia afzelii (OspA ST2), Borrelia garinii (OspA ST3, OspA ST5, and OspA ST6), and Borrelia bavariensis (OspA ST4). In VLA15 The protein backbones of all six chimeric variants were based on the sequence of the C-terminal fragment of afzelii OspA ST2, which represents the most prevalent OspA ST causing LB in Europe. My questions: How protective will VLA15 be against other forms of Borrelia found in the United States

Carrano AC, Eytan E, Hershko A, Pagano M

The 14 viral ORFs interact with a few thousands of human metabolites in a specific manner for its intra-cellular invasion, replication, and transmission, which results in HMRD in favor of the viral pathogen