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30,32 Consequently, activation of the Keap1-Nrf2 pathway serves as a defense mechanism to strengthen the antioxidant system and minimize the detrimental effects of oxidative stress in the liver caused by NAPQI

This paper demonstrates the advantages of direct reprogramming of ALS patient fibroblasts, via induced neural progenitor cells, into astrocytes, which are toxic to motor neurons in coculture and are non-clonal and retain the epigenetic features of ageing

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Abbreviations 4-HNE: 4-Hydroxy-2-nonenal AIF: Apoptosis-inducing factor AKAP-121: A-kinase anchoring protein 121 Akt/PKB: Protein kinase B AMI: Acute myocardial infarction AMPK: AMP-activated protein kinase ANT1: Adenine nucleotide translocator 1 CaMKII: Ca 2 + /calmodulin-dependent protein kinase II CCR2: CC chemokine receptor type 2 cGMP: Cyclic guanosine monophosphate circRNA: Circular ribonucleic acid DOCA: Deoxycorticosterone acetate Dok-4: Docking protein 4 EMPA: Empagliflozin ERK1/2,: Extracellular signal-regulated kinase 1/2 EVs: Extracellular vesicles Fer-1: Ferrostatin-1 gp130: Glycoprotein 130 GPCR: G-protein coupled receptor GSH: Glutathione GSK-3: Glycogen synthase kinase-3beta HSPA12B: Heat shock protein A12B IL-6: Interleukin-6 IL-37: Interleukin-37 lncRNA: Long non-coding RNAs IPC: Ischemic preconditioning IRI: Ischemia/reperfusion injury JAK: Janus kinase JNK: C-Jun N-terminal kinase Lck: Lymphocyte-specific protein tyrosine kinase MACE: Major adverse cardiovascular events MEK: Mitogen-activated protein kinase kinase MEKK1: Mitogen-activated protein kinase kinase kinase 1 Mfn1: Mitofusin-1 Mfn2: Mitofusin-2 MIF: Macrophage migration inhibitory factor MLKL: Mixed lineage kinase domain-like protein mPTP: Mitochondrial permeability transition pore mtDNA: Mitochondrial DNA NAC: N -Acetylcysteine ncRNAs: Non-coding RNAs NGF: Nerve growth factor NLRP3: NLR family pyrin domain containing 3 protein NO: Nitric oxide NPs: Natriuretic peptides Nrf2: Nuclear factor erythroid 2-related factor 2 p38: P38 mitogen-activated protein kinase PAR: Poly(ADP-ribose) PARP-1: Poly (ADP-ribosome) polymerase 1 PDE5: Phosphodiesterase type 5 pGC: Particulate guanylate cyclase PI3K: Phosphatidylinositol-3-kinase PINK1: PTEN-induced putative kinase 1 Pitx2: Pituitary homeobox 2 PKC-: Protein kinase C epsilon PKG: Protein kinase G PostC: Ischemic postconditioning PRRs: Pattern recognition receptors PTEN: Phosphatase and tensin homolog RIC: Remote ischemic conditioning RIPK1: Receptor-interacting protein kinase 1 RIPK3: Receptor-interacting protein kinase 3 RISK: Reperfusion injury salvage kinase SAFE: Survivor activating factor enhancement SFKs: Src-family kinases sGC: Soluble guanylyl cyclase SR: Sarcoplasmic reticulum Src: Proto-oncogene tyrosine-protein kinase SSO 2 : Supersaturated oxygen STAT3: Signal transducer and activator of transcription 3 TAZ: Tafazzin TEAD4: TEA domain transcription factor 4 TLR4: Toll-like receptor 4 TNF-: Tumor necrosis factor TNF-R: Tumor necrosis factor receptor VDAC: Voltage-dependent anion channel YAP: Yes-associated protein References Abe J, Yamada Y, Takeda A, Harashima H (2018) Cardiac progenitor cells activated by mitochondrial delivery of resveratrol enhance the survival of a doxorubicin-induced cardiomyopathy mouse model via the mitochondrial activation of a damaged myocardium