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The 2022 Dimet-Wiley paper in Scientific Reports characterised NNMT inhibition combined with reduced-calorie diet in diet-induced-obesity mouse model systems (PMID 35013352)

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Certain cancers, especially those of the stomach, pancreas, or blood (such as leukemia or lymphoma), can impact available Vitamin B12 by either blocking or disrupting the bodys absorption and/or increasing the physiological need for Vitamin B12

This selectivity, combined with its ability to efficiently cross cellular membranes, makes it an invaluable research tool for dissecting the specific contributions of NNMT to metabolic regulation