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Pharmacokinetic Profile Route of Administration Subcutaneous Dosing Frequency Once daily Route of Administration : Subcutaneous injection Dosing Frequency : Once daily Half-Life : ~38 minutes in HIV+ patients 2 Formulation : Lyophilized acetate salt for reconstitution Formulation & Handling Reconstitute lyophilized powder in sterile bacteriostatic water for injection (0.9% benzyl alcohol) Store reconstituted solution at 28C and use within 14 days Unreconstituted vials should be stored at 20C in a dry, light-protected environment Avoid repeated freeze-thaw cycles

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Critical role of AMPK in redox regulation under glucose starvation