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Clinical Presentation Acute overdosage with Hydrocodone Bitartrate and Acetaminophen Tablets can be manifested by respiratory depression, somnolence progressing to stupor or coma, skeletal muscle flaccidity, cold and clammy skin, constricted pupils, and, in some cases, pulmonary edema, bradycardia, hypotension, hypoglycemia, partial or complete airway obstruction, atypical snoring, and death

S2CID 29165746

Without this hormone doing its job, your kidneys start flushing out water like there's no tomorrowhence those frequent bathroom trips during a night out and that cotton-mouth feeling the next morning

References Sun X, Deng Y, Fu X, Wang S, Duan R, Zhang Y