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[DOI] [PMC free article] [PubMed] [Google Scholar] 76.Deigendesch N., Sironi L., Kutza M., Wischnewski S., Fuchs V., Hench J., Frank A., Nienhold R., Mertz K.D., Cathomas G., Matter M.S., Siegemund M., Tolnay M., Schirmer L., Prbstel A.K., Tzankov A., Frank S

156 Spermidine, a polyamine that enhances autophagic flux, improves insulin resistance and gut health in preclinical models, although its translational potential remains limited by the lack of robust human data

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Some researchers think this effect could support overall mental clarity, cognitive performance, and brain function