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16 :e0259436 160

10.2147/CIA.S114515 100

The activation of transcription factors like nuclear factor kappa B (NF-B) and activator protein-1 (AP-1) by ROS is particularly significant in cancer

Figure 1 4.4 Cholinergic system modulation by naringenin: inhibition of cholinesterases and enhancement of cognitive function Modulation of the cholinergic system remains a core therapeutic target in AD, primarily due to the progressive loss of cholinergic neurons and the decline in acetylcholine (ACh) levels that characterize the disease (Hampel et al., 2018)