multidrug resistance protein 1 glutathione ABCC1 Inhibition of the Multidrug Resistance

The ferroptosis pathways within nerve cells include iron homeostasis regulation, cystine/glutamate (Glu) reverse transporter (system xc ), glutathione (GSH)/glutathione peroxidase 4 (GPX4), and lipid peroxidation

Nonetheless, the increased demand for energy and building blocks for macromolecule synthesis upon mTORC1 activation, together with the block in autophagy, results in a biosynthetic burden that the cell alleviates with the execution of parallel programs that reinforce nutrient uptake (Torrence et al., 2020) and synthesis (Valvezan et al., 2017), and also enables the catabolic capacity of the cells through the proteasomal degradation of proteins (Zhang et al., 2014) to remove unwanted cellular material and to boost the pool of free amino acids available for protein synthesis

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Adv Drug Deliv Rev 2008