glutathione peroxidase hydroxyl radical 3 - an overview 1: Detoxification of oxidizing species.

Might explain why people with high uric acid have about a 35% increased risk of ischemic stroke, a 40% increased risk of dying from a cardiovascular event, because nitric oxide is compromised, blood vessels can't do what they need to do

10.1016/j.tim.2015.03.002 39 DerrienM.van PasselM

indicated that GPX4 and GSH levels were decreased, and cellular iron and MDA levels were increased in a mouse model of myocardial ischemiareperfusion (MIR, ischemia 30 min and reperfusion 24 h) injury [90]

Taken together, our results demonstrate that hemin, in contrast to inorganic iron, generates ROS, DNA strand breaks and oxidative DNA damage in both normal HCEC and CRC cells