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Small-molecule drugs are organic compounds that have a low molecular weight and could target regulatory proteins as a method for probing biologically relevant molecular pathways such as ferroptosis [117]

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The best strategy to prevent increased glutamate concentrations is to maintain bioenergetic processes in neurons and astrocytes at high activity levels and to activate glycine-dependent processes

Most available evidence suggested that glomus (type I) cells are the initial sites of transduction and they release transmitters in response to hypoxia, which in turn depolarize the nearby afferent nerve ending, leading to an increase in sensory discharge