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Molecular analyses confirmed histone modifications in the promoter regions of leptin and adiponectin, including reduced H3K9 acetylation and increased H3K9 demethylation and H4K20 monomethylation, consistent with altered gene transcription and circulating adipokine levels [176]

In hepatocytes and adipocytes it reduces the activity of key lipogenic enzymes: Acetyl-CoA carboxylase (ACC) , a key step in fatty acid synthesis Fatty acid synthase (FAS) , the enzyme creating long chains of fatty acids Lipoprotein lipase (LPL) in adipocytes, reduces uptake of circulating triglycerides into fat cells Imagine it as turning valves in a pipeline, you close the inflow (lipogenesis), open the outflow (lipolysis)

The treatment involves modulating the way pain signals are transmitted and processed and the resulting pain relief can last for weeks/ months