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Soluble oligomeric A has been shown to induce oxidative stress and has been proposed to play a central role in the oxidative damage detected in AD brain (Xu et al., 2014)

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These results further demonstrated that the Gi-F-CAA showed tremendous advantages in overcoming the bottleneck of tumor accumulation

An RCT of 174 patients with severe alcoholic hepatitis found that the combination of prednisolone + NAC (IV for 5 days, then oral for 2 weeks) significantly reduced 1-month mortality compared to prednisolone alone (8% vs 24%, p=0.006), though the difference was not significant at 6 months (Nguyen-Khac et al., N Engl J Med, 2011) [36]