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The traditional heme production method extracts hemoglobin from the blood of pigs or other animals and then prepares free heme through enzymatic hydrolysis

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Actin depolymerization of phagosomes was also ASMase-dependent in the BMMs because imipramine treatment of WT BMMs increased the ratio of cells possessing actin-coated phagosomes ( Figure 7D ), indicating that not only cell lines but also primary Ms use the SM-ceramide-axis to control phagosomal actin