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Mechanical stress can arise from hypermobility and overloading of the disc in the early stages of IDD, which is then generally followed by limited motion and hypomobility in the later stages (Stokes and Iatridis, 2004)

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The 2015 Pickart-laboratory review compiled the multiple cellular pathways modulated in skin-regeneration model systems, including collagen and elastin synthesis stimulation, fibroblast migration, and matrix-deposition findings (PMID 26236730)

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