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Ubiquitination regulation of HIF-1 The controlled regulation of protein turnover is crucial for maintaining stable cell structure and function

10.1161/CIRCRESAHA.119.314681 59 WanS.ZhangG.LiuR.AbbasM

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Thus, in summary, using three tag-free solution based techniques we discovered that the interaction involves two regions within CEP192 and the N-lobe of Aurora-A, and is more extensive than was reported in a crystal structure of Aurora-A kinase domain fused to a CEP192 peptide (aa 506527) (Park et al, 2023)