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Selenium serves as a key cofactor for glutathione peroxidase, an enzyme critical to antioxidant recycling

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FIGURE 4 Glutathione Peroxidase 4 and Selenoprotein S Were Involved in 2-Hydroxy-4-Methylselenobutanoic Acid Alleviating Reactive Oxygen Species Induced Endoplasmic Reticulum Stress in Porcine Intestinal Epithelial Cells In order to elucidate the role of GPX4 and SELS in regulating ER stress, we performed gene knockdown study with GPX4 and SELS in IPEC-J2 cells