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Research has also examined its role in upregulating matrix metalloproteinase (MMP) activity alongside their inhibitors (TIMPs), suggesting a finely balanced role in extracellular matrix remodelling rather than simple collagen deposition

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Hence, estrogen pathways lead to an inflammatory state and disturbances in the immune environment, which affect morphological and biochemical changes associated with endometrial tolerance, resulting in pregnancy outcomes

It is often discussed for its potential role in supporting healing, especially in tendons, ligaments, muscles, joints, nerves, and other connective tissues