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Additionally, the combined expression of IL-17A, IL-17F, IL-21, retinoic acid receptor-related orphan receptor C (RORC), and transforming growth factor (TGF)- mRNA significantly predicted the rachmilewitz endoscopic index (REI), with IL-17A and IL-17F being associated with increased and decreased REI, respectively [67]

Huang SK, Wettlaufer SH, Chung J, Peters-Golden M

Nevertheless, emerging data allow us to propose that severe hyperhomocysteinemia might primarily have homocysteinylation effects related to homocysteine and/or its by-products (as homocysteine thiolactone) that would affect the vascular wall structure through a mechanism independent of an oxidant stress