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The oxidative damages of biomolecules specifically of DNA due to the accumulation of hydroperoxides and other ROS ultimately lead to the loss of cell viability or cell death through various death mechanisms like apoptosis, autophagy, necrosis, ferroptosis, and mitotic catastrophe (Fig

J Exp Bot 66:28392856 Yabuta Y, Maruta T, Nakamura A, Mieda T, Yoshimura K, Ishikawa T, Shigeoka S (2008) Conversion of L-galactono-1,4-lactone to L-ascorbate is regulated by the photosynthetic electron transport chain in Arabidopsis

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Our work identifies SLC25A39 as an essential and regulated component of the mitochondrial GSH-import machinery