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Pathological alpha-synuclein transmission initiated by binding lymphocyte-activation gene 3

Microglial recruitment was related to elevated levels of TNF and the consequent formation of CC-motif chemokine ligand 2 (CCL2) that forms part of the so-called chemokines.62 Those findings have suggested that there is a new immune-to-brain communication pathway, resulting in altered excitability and neurologic complications in patients with cholestatic liver disease

In vitro animal models have also confirmed the prothrombotic effect of TMAO by enhancing platelet aggregation (Zhu et al., 2016)