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Primary fibroblasts are easily obtained during muscle or skin biopsy and fibroblasts culture is highly proliferative, providing a renewable source of cells in vitro (Hu et al., 2019)

References Peng F, Liao M, Qin R, Zhu S, Peng C, Fu L, et al

The exact genesis of immunological tolerance is still elusive, but several theories have been proposed since the mid-twentieth century to explain its origin