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10.1074/jbc.M110.136911 [DOI] [PMC free article] [PubMed] [Google Scholar] Polycarpo C, Ambrogelly A, Ruan B, Tumbula-Hansen D, Ataide SF, Ishitani R, Yokoyama S, Nureki O, Ibba M, Sll D

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It has been reported that essential hypertension is characterized by increased ET-1-mediated vasoconstrictor tone, which is an effect that seems to be dependent on decreased endothelial ET B -mediated NO production that is attributable to the impaired NO bioavailability