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Unlike classical protonophores such as FCCP and 2,4-dinitrophenol which cause rapid and complete collapse of the mitochondrial membrane potential, leading to full depolarization, severe off-target effects including plasma membrane disruption and dose-dependent cytotoxicity (55), fatty acid anion transporters such as SR4 may provide greater mitochondrial specificity and safety through gradual, physiologically controlled depolarization

[DOI] [PubMed] [Google Scholar] 138.Lees C, Langford E, Brown AS, de Belder A, Pickles A, Martin JF, Campbell S

The development of these pathologies requires the presence of a favorable genetic background (61), where adjuvants might induce an exacerbated immune response causing adverse reactions without necessarily involving resolution of pathological condition ( A classic example of ASIA is the autoimmune complications of immune checkpoint inhibitor (ICI) therapy used in cancer treatment, known as immune-related adverse events (irAEs) (61, 64)

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