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However, inhibition of hexokinase would abolish NADPH production from the oxidative phase of the pentose phosphate pathway, as no other metabolic rewiring can replace this

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Furthermore, we establish that the reprogramming of glutamine metabolism is mediated by oncogenic KRAS, the signature genetic alteration in PDAC, through the transcriptional upregulation and repression of key metabolic enzymes in this pathway

These cellular causes of aging have been well characterized and are collectively referred to within the aging research community as the hallmarks of aging. 1 The identification of the hallmarks of aging has marked a shift toward understanding aging not as a single process, but instead as a combination of multiple cellular changes