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Two neuronal subpopulations present modifications in activity due to signals from the periphery, which includes the pancreas, adipose tissue, and the gastrointestinal tract ( Figure 1 One of these populations is represented by appetite-suppressing neurons, which function in these ways: 1

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However, these approaches face inherent challenges: Neurons have limited regenerative capacity, are highly susceptible to metabolic stress, and require preservation of precise synaptic connectivity for proper network integration

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