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Box: Hydroxocobalamin dosing schedule for the management of pernicious anaemia If no neurological involvement: Loading dose: 1,000 micrograms three times per week for two weeks Maintenance dose: 1,000 micrograms every two to three months If neurological involvement: Loading dose: 1,000 micrograms every other day until no further improvement Maintenance dose: 1,000 micrograms every two months Injections are usually administered at a GP surgery, although some patients can be taught to self administer[22]

Generally there may also be joint pains (arthralgias), Carpal Tunnel Syndrome, congestive heart failure, thyroid deficiencies (Hashimoto's thyroiditis), inflammation and degneration of connective tissue (Polymyositis), malignant tumors (neoplasms), deficiency in secretion of tears (Sjogren's syndrome), Raynaud's phenomena, Rheumatoid Arthritis, and Systemic Lupus Erythematosus

BPC-157 lowers pro-inflammatory cytokines such as Tumor Necrosis Factor-alpha (TNF-) and Interleukin-6 (IL-6), reducing immune-driven tissue damage, while activating epithelial and fibroblast cells to regenerate the mucosal lining

This effect can cause or worsen gastroparesis