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42 In another study in beagles in a research setting, measures of oxidative stress (malondialdehyde or MDA) were higher in older dogs, along with apparently compensatory increases in both glutathione peroxidase and SOD activities

268 For example, high levels of Cu have been found in senile plaques and serum in patients with AD, 269,270 and high concentrations of Cu have also been measured in A plaques in the dentate gyrus subregion of the hippocampus in a mouse model of AD