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iii) feedback regulation, involving the JNK/Beclin-1, NRF2/p62 and ROS/AMPK pathways, creating a bidirectional adaptive loop

This change tendency in both GCLC succinylation and GSH synthesis showed a similar pattern as the one in culturing cells, strongly supporting that oxidative damage induces GCLC desuccinylation and promotes GSH synthesis in vivo

10.1177/1945892420953351 139 ThakurK.ZhuY.-Y.FengJ.-Y.ZhangJ.-G.HuF.PrasadC.et al (2020)