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Kleinewietfeld et al

The symbiosis between two prokaryotes produced the development of mitochondria and the start of all actual living organisms including plants Figure 1

In addition, the tumor suppressor BAP1 decreases H2Aub occupancy on the SLC7A11 promoter and represses SLC7A11 expression in a deubiquitinating-dependent manner, that is, BAP1 inhibits cystine uptake by repressing SLC7A11 expression, leading to elevated lipid peroxidation and ferroptosis rates [54]