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Description

In our study, transient ROS-scavenging was not able to revert these modifications and to reinstate the functionality of these cells

Discovery and pharmacological characterization of a new class of prolyl-tRNA synthetase inhibitor for anti-fibrosis therapy

MYCN -amplified HR-NB tumors, which have high metabolic needs, are dependent on iron and cysteine (key for glutathione production), making them potentially sensitive to ferroptotic cell death 7,8,9