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A striking example is curcumins synergy with antibiotics against resistant organisms: curcumin greatly improved the efficacy of polymyxin and vancomycin against both Gram-negative and Gram-positive pathogens by increasing cell membrane permeability and blocking drug efflux ( Candida (fungal) cells as wellcurcumin interacts with membrane ergosterol, akin to polyene antifungals, leading to membrane destabilization

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10 M-50 M) shows a significant 1.2- to 1.7-fold increase in human astrocytoma U373-MG cells after 48 h of treatment with various Nrf2 activators, compared with control cells [1]

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