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For example, while low-dose polyphenols stimulate endogenous antioxidant defenses, high concentrations, such as those found in concentrated supplements, can act as potent pro-oxidants, leading to increased oxidative stress and cellular damage 51

Analysis of ratios of Gln-to-Glu (Gln/Glu) and Glu-to-GABA (Glu/GABA) As measures of Gln-Glu cycling and E/I balance, respectively [54,55,56], mean Gln/Glu and Glu/GABA ratios were calculated across the three VOIs (ACC, thalamus, and rTPJ) for each subject