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Frontiers in Endocrinology (Lausanne) , 14 , 1217165

Abbreviations TCM: Traditional Chinese medicine RANKL: Receptor activator of nuclear factor-B ligand TRAP: Tartrate resistant acid phosphatase BMD: Bone mineral density Cat-K: Cathepsin K MSCs: Mesenchymal stem cells ROS: Reactive oxygen species H 2 O 2 : Hydrogen peroxide SOD: Superoxide dismutase GSH: Glutathione reductase CAT: Catalase MDA: Malondialdehyde Prdxs: Peroxiredoxins GPX: Glutathione peroxidase NQO1: NADPH ubiquinone oxidoreductase Runx2: Runt-related transcription factor 2 COL1 A1: Collagen type I alpha 1 ALP: Alkalinephosphatase BALP: Bonealkalinephosphatase OC: Osteocalcin OPN: Osteopontin BSP: Bone Sialoprotein Osx: Osterix TGF-: Transforming growth factor BMP: Bone morphogenetic protein COL-I : Collagen-I TFRD: Total flavonoids of rhizoma drynariae PGE2: Prostaglandin E2 Keap1: Kelch-like ECH-associated protein 1 Nrf2: Nuclear factor erythroid-2-related factor 2 ARE: Antioxidant response element HO-1: Heme oxygenase-1 SA: Saikosaponin A BV/TV: Bone volume fraction Tb.N: Trabecular number Tb.Th: Trabecular thickness Cytc: Cytochrome c AMPK: Adenosine 5-monophosphate (AMP)-activated protein kinase eNOS: Endothelial nitric oxide synthase PI3 K: Phosphoinositide-3 kinase Akt: Protein kinase B mTOR: Mechanistic target of rapamycin Tb.Sp: Trabecular separation/spacing PINP: Propeptide of type I procollagen DPD: Deoxypyridinoline VEGF: Vascular endothelial growth factor HIF-1: Hypoxia-inducible factor 1 alpha ANGPTL4: Angiopoietin-like protein 4 IL: Interleukin MOB: Mouse primary osteoblast PICP: Procollagen type I carboxy-terminal peptide CTX: C-terminal telopeptide of type I collagen NTX: N-terminal telopeptide of type I collagen SIRT1: Silent information regulator 1 FoxOs: Forkhead Box O NF-KB: Nuclear factor kappa-B DOP: Diabetic osteoporosis TNF-: Tumor necrosis factor- NLRP3: NOD-like receptor thermal protein domain associated protein 3 TRAF6: Tumor necrosis factor receptor-associated factor 6 NFATc1: Nuclear factor of activated T cells 1 Gene PPAR: Peroxisome proliferator-activated receptor C/EBP: CCAAT/enhancer-binding protein References Anam AK, Insogna K

However, if youre looking to detox and brighten then glutathione will be your go to ingredient as it brings vibrancy to the skin and protects it from oxidative stress and environmental damage

The hydrocarbons are diverse and include: non-oxygenated hydrocarbons such as megastigma-3,7(E),9-triene, dihydrocurcumene, and -curcumene