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This network approach was chosen to integrate complex metabolic data and highlight potential mechanistic connections, allowing us to identify functional relationships that may underlie the effects of NPs-FM19G11 treatment

Introduction Following cessation of antiretroviral therapy (ART) in people with HIV (PWH), HIV rapidly rebounds from a pool of latently infected cells ( Several classes of LRAs with distinct mechanisms of action have been described, and many have demonstrated strong induction of HIV RNA in vitro and ex vivo ( in vivo , of which a common primary endpoint for efficacy has been cell-associated, unspliced HIV RNA as a measure of HIV reactivation (see ( This lack of potency of current LRAs is thought to be due to two reasons

doi: 10.1016/j.ecl.2006.11.003 88 RamrezJLGraciaNavarroFGarcaNavarroSTorronterasRMalagnMMCastaoJP