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Diabetic neuropathy (nerve damage) causes symptoms like tingling, numbness and burning in the limbs

10.1016/j.semnephrol.2009.07.002 126 MelkA.RamassarV.HelmsL

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Either an irreversible inhibitor of SERCA (thapsigargin, TG) or the physiological Ca 2+ mobilizing agents histamine [24] and cholecystokinin [23] rapidly transformed the ER luminal environment into a more reducing milieu