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Description

They also had lower levels of AST (aspartate aminotransferase) and CK (creatine kinase), two key markers of muscle damage

The LRRK2 inhibitor DNL201 ( BIIB122 ) has shown target engagement and satisfactory safety in phase 1/2 studies [201, 202] and is currently tested in a phase 2 trial enrolling PD patients with LRRK2 mutations (BEACON

PMID: 48 MillerYIChoiS-HWiesnerPFangLHarkewiczRHartvigsenKet al

In the STEP2 focusing on 1,210 patients with obesity or overweight and T2D, average weight loss with semaglutide 2.4 mg therapy was 6.2% compared to the placebo [47]