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At lower concentrations, they have beneficial effects and indulged in different physiological processes such as redox regulation, mitogenic responses, cellular signaling pathways, and an immune function while at a higher level, these reactive species generate nitrosative and oxidative stress (Phaniendra et al., 2015)

26 In vivo, the combination of ibrutinib and RSL3 was superior to either monotherapy alone, both of which significantly delayed disease progression, further supporting our previous observations (Fig

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