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Beyond the handling ability of lysosomes, there was a burst of Zn to other subcellular organelles such as mitochondria, disrupting cellular homeostasis and causing cellular toxicity

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When the air temperature was rapidly decreased from 89F to 54F (32C to 12C), women in their luteal phase (and those on oral contraceptives) started shivering at higher core body temperatures indicating an increased sensitivity to the cold 1

Zheng H, Cheng ZJ, Liang B, Wang ZG, Tao YP, Huang SY, Ni JS, Li HF, Yang L, Yuan SX, Wu J, Kawaguchi T, Samant H, Zhou WP, Xiang DM, Yang Y