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While subcutaneous injection into the lower limbs may be possible, it is generally not recommended as a preferred injection site due to the possible complications involved including tissue damage and injection site reactions: The skin in the lower limbs is typically thinner and more sensitive than other parts of the body, which can increase the risk of pain, bleeding, and infection

Corsini EM, Zhou N, Antonoff MB, Mehran RJ, Rice DC , Roth JA, Sepesi B, Swisher SG, Vaporciyan AA, Walsh GL, Hofstetter WL

Local injection of the drug into spasmed muscles leads to: long-term relaxation

Using Both Together: Potential Synergistic Benefits While each product works very well on its own, some patients and providers choose to use GHK-Cu topical alongside a tretinoin/niacinamide formulation for complementary effects