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10.2478/acph-2013-0021 215 TianB.HuaS.LiuJ

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Research has revealed that abnormal regulation of N6-methyladenosine (m6A) modification in HGSOC cells is closely associated with tumor occurrence and metastasis ( Furthermore, the activation of the mTOR signaling pathway is associated with the upregulation of FANCD2, which may regulate sensitivity to platinum-based drugs by affecting the expression of DNA crosslink repair proteins, thereby influencing drug resistance in HGSOC ( 3.5 Non-coding RNAs In the complex pathogenesis of High-Grade Serous Ovarian Carcinoma (HGSOC), multiple non-coding RNAs (ncRNAs) play crucial regulatory roles ( MicroRNAs (miRNAs) play a crucial role in post-transcriptional regulation by binding to target gene mRNAs, inhibiting their translation or promoting their degradation ( Some lncRNAs promote tumor cell proliferation and metastasis by regulating gene transcription and translation ( circRNA as a novel non-coding RNA, has gradually revealed its functions in High-Grade Serous Ovarian Carcinoma (HGSOC)