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Both peptides trigger this release through the growth hormone secretagogue receptor (GHS-R) not the normal growth hormone-releasing hormone (GHRH) pathway

He reviewed some peptides that had been approved for specific indicationsand thus could safely be prescribed to patients for other conditionsbefore turning his attention to gray-market peptides

"Ipamorelin induces pulsatile GH release with minimal off-target effects, providing an effective means of enhancing recovery, tissue repair, and overall anabolic environment with a favorable safety profile." Kraemer et al., Sports Medicine Clinical Evidence Ipamorelin has been shown to elevate GH and IGF-1 levels without causing significant increases in cortisol or prolactin, making it an attractive choice for athletes focused on recovery

This selectivity makes ipamorelin a valuable research tool for investigating GH secretion pathways independently of hypothalamic-pituitary-adrenal (HPA) axis activation